To Record Poisoning Related Changes In Liver Autopsy

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Dr. Ajay Y. Pednekar , Dr. Nelson Nishant Kumar Lyngdoh , Dr.Chandrakant M.Kokatanur


Aim: To assess poisoning related changes in liver autopsy.

Materials & methods: A total of 50 cases of liver autopsy findings were recorded. A Performa was made and gross findings were recorded separately. Before starting of the study, ethical approval was obtained from institutional ethical committee. Each autopsy was treated as a special research project. Special morphological examinations of the viscera were routinely performed. All the results were recorded in Microsoft excel sheet and were analysed using SPSS software.

Results: In 40 percent of the cases, ethyl alcohol was the etiologic poisoning agent. Organochlorous and Carbamate were reported in 17 percent and 10 percent of the cases while Organ-phosphorous were responsible in 15 percent of the cases. On assessing the morphological findings, hepatic enlargement was seen in 5 percent of the cases while it was congested in 81 percent of the cases. On evaluating the histopathologic findings, fatty changes were seen in 51 percent of the patients while congestion was seen in 40 percent of the patients.

Conclusion: From the above results, the authors conclude that histopathological examination can support to estimate cause of death due to poisoning with fatty change being the most common findings.

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