EFFECT OF SODIUM BICARBONATE AS A PREMEDICATION ON INCREASED CEREBRAL RESISTANCE TO ACUTE HYPOXIA

Abstract

Background: Sodium bicarbonate injection can prevent brain trauma and serious internal problems. Since brain neuronal damage can be caused by an acute event such as hypoxia or cardio-respiratory arrest, prevention of severe acidosis can protect brain cells.
Methods: We used Mus Masculus and BALB / C mice weighing 25 -35 g, aged 8 to 12 weeks old, from the Shohada-e-Tajrish Laboratory Animal Center, Tehran, Iran. Sodium bicarbonate (SB) (4meq / kg) was injected to the mice at different times and the rate of immobility and respiratory arrest induced by acute hypoxia was measured.
Result: In the study group, we first developed acute hypoxia inside the anesthesia chamber and completed hypoxia by adding CO2. The experimental group underwent acute hypoxia, and showed slightly longer resistance than the control group. Bicarbonate (4meq / kg, IP) was injected to animals 60 min, 6 h, 12 h, and 24 h before acute hypoxia.
Conclusion: In this study, SB at doses above 4meq / kg had a significant effect on hypoxia and led increased resistance to acute hypoxia.