Detection of subtle ventricular systolic dysfunction in Egyptian patients with type 2DM and Acanthosis nigricans using 2-D speckle tracking echocardiography

Main Article Content

Eman Rashed Zaki , Nadia Ahmed Agiba , Mostafa Ismael saleh , Mahmoud Saeed Mahmoud , Marwa Said

Abstract

Background: Egyptian patients (pts) have a high prevalence of  Type 2 Diabetes Mellitus (DM). A skin condition characterized by a velvety papillomatous overgrowth of the epidermis. Darkening and thickening (hyperkeratosis) of the skin occurs mainly in the flexural areas, particularly the axillae, groins, inframammary regions, and the neck. Called Acanthosis nigricans which is usually a sign of underlying diabetes.  Type 2DM often presents with comorbidities & develops heart failure (HF) more frequently. Two-Dimensional Speckle Tracking Echocardiography (2D-STE) allows a precise evaluation of myocardial function. Aim of work: Detection of subtle ventricular systolic dysfunction in Egyptian patients with type 2DM  and Acanthosis nigricans   using 2-D STE. Patients & methods: The study included 80 Egyptian pts with Acanthosis nigricans and type 2 DM   in addition to 40 Egyptian healthy subjects as a control group (GII) using conventional 2-D Echo-Doppler, Tissue Doppler Imaging (TDI), and 2D-STE. LV dimensions, volume, ejection fraction (EF), RV FAC, TAPSE, MV &TV velocities, were measured.Results: Despite both groups showing no statistically significant differences regarding LV & RV systolic function by conventional echo (LV EF, RV FAC, and TAPSE), GI had significantly lower LV & RV GLPS compared to GII (16.73±3.4 Vs 18.5±1.1 with P =0.022 &-19.19 ±3.8 Vs 23±2.3 with P ≤0.001 respectively). LV& RV GLPS showed significant negative correlations with HbA1C, while LV GLPS showed a positive correlation with RV GLPS. Conclusion left & right ventricular systolic function were sub-clinically affected in Egyptians Type 2 diabetic patients with  Acanthosis nigricans  using 2D-STE 

Article Details

Section
Articles