Parkinson’s Disease- Etiology, Clinical Features, And Its Therapy: A Review

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Dr. J. Narayanan, Dr. T. Tamilanban, Dr. V. Manimaran, Dr. V. Chitra


The second most common age-related chronic progressive neurological condition is Parkinson's disease (PD), the first being Alzheimer's disease.  Trembling, bradykinesia, muscle rigidity, and impaired gait and posture are the main characteristics of the disease.  Motor deficiencies that characterize Parkinson's disease (PD) are due to the gradual degenerations of neurons in substantia nigra pars compacta (SNpc) leading to reduced dopamine levels in striatum. The most widely used treatment for PD are only partial or reversible and are accessible to only marginal group of patients. Since these remedies do not recover the damaged and degenerated dopaminergic neurons, also does not reduce or stop the progression of the disease, the need for more successful treatment is essential. This review provides a summary of the etiology involved in PD, the clinical symptoms, and its treatment.

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