Analysis Of Effective Anti-Hypertensive Combination Therapy Out Of Angiotensin Receptor Blocker With Calcium Channel Blocker Versus Angiotensin Receptor Blocker With Diuretics In Newly Diagnosed Hypertensive Patients In A Tertiary Care Hospital

Abstract

Background:

Developing Countries have undergone rapid industrialization, urbanization, globalization and economic development over the last four decades. Therefore, standard of living has improved but with a detrimental shift toward inappropriate dietary patterns and reduction in physical activities. This health transition will ultimately affect the health of young adults with people in reproductive age group of present generation. Prevalence of Hypertension in India ranges from 17% to 29.8%. Cardiovascular diseases are the leading cause of death globally, accounting for approximately 31% of all global deaths. Increased blood pressure is one of the important risk factors of cardiovascular disease. According to the WHO’s World Health Statistics Report 2012, 21% world’s adult population has raised blood pressure – a condition responsible for half of all deaths from stroke and heart disease. Hypertension contributes to 4.5 percent of the current global disease burden. The prevalence of hypertension among young adults is on a steady rise

Objective: Analysis of effective Anti-Hypertensive Combination therapy out of Angiotensin Receptor Blocker with Calcium Channel Blocker Versus Angiotensin Receptor Blocker with Diuretics in newly diagnosed hypertensive patients in a Tertiary Care Hospital

Material &Methods: a prospective observational randomized control study from sep-2021 to Feb-2022, after obtaining the necessary clearance from the institutional Ethical Committee. We included those, who attended the medicine outpatient department with a diagnosis of newly diagnosed essential hypertension of 18 to 50 year of age and excluded those with secondary hypertension

Result &Discussion:

Out of 60 hypertensive patients under evaluation 42 were males (70%) with an M: F ratio of 2.3:1. In ARBs + CCBs (Group A) there are 23 male patients (76.67%) and 7 females (23.33%), while in ARBs + Diuretics (Group B) there are 19 males (63.33%) and 11 females (36.67%)

Conclusion:

Through this study we conclude that ARBs + CCBs (Group A) drug combination is more effective than ARBs + Diuretics (Group B) drug combination in reducing the blood pressure