Novel Anilino Coumarins' Multistep Production And In Vitro Bio-Evaluation

Abstract

This research provides a simple and environmentally friendly multistep process for the synthesis of amino substituted coumarin (5a-5g) using glacial acetic acid, 73% H₂SO₄, and 5% HCl as solvents in the condensation reaction between -naphthol (1) and ethyl-4-chloroacetoacetate (2). Through thin layer chromatography and melting point, the purity of the chemicals that were converted was shown. All synthetic compounds have undergone thorough characterization using Data from NMR and FTIR spectroscopy and their effectiveness as an in vitro herbicide against seeds of Raphanus sativus L. (Radish) has also been evaluated. The substances antibacterial activity against Bacillus had also been shown. Antifungal activity turned into also determined towards strategies technique. From result of activity data, it became determined that compounds 5c and 5g had been confirmed highest growth inhibition against R. sativus L. (root) and R. sativus L. (shoot), respectively. Compounds 5b, 5c and 5g were located maximum energetic against Bacillus species at all of the concentrations. Compound 5c become confirmed maximum fungal toxicity in opposition to Rhizoctonia solani.