Development Of Fast Dissolving Tablets of Atenolol Using Solid Dispersion Technology

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Manimaran V, S. Harshavardhan Reddy, Kalaiselvi S, Damodharan N, Tamilanban T, Narayanan

Abstract

Context: The solid dispersion (SD) dosage plays a vital role in formulating some poorly water-soluble drugs as fast-dissolving dosage forms by modifying the additives and procedures. SD belongs to the combination of solid products composed of two ingredients, usually a hydrophilic carrier & a hydrophobic matrix; where the matrix could be either amorphous or crystalline in form. Amlodipine, a calcium channel blocker widely being employed in hypertension and angina. The fast disintegrating nature of SD amlodipine enhances its rapid action and pharmacodynamics properties. Aim: To develop the fast dissolving solid dispersion formulations of Atenolol employed in the management of Hypertension. Settings and Design: Solvent evaporation process was employed in this study to prepare the solid dispersion dosage forms of Atenolol using methanol as a solvent.


Methods and Material: The solid dispersion formulations of Atenolol were prepared and evaluated for the XRD, SEM and dissolution. Invitro dissolution analysis was also performed. Results: The drug content uniformity studies, X ray diffraction studies, dissolution studies and scanning electron microscopy was performed to the solid dispersions and indicates the crystalline nature of the preparation. Pre formulation studies have provided an evidence that the powder was suitable for compression process. The atenolol fast dissolving tablets were observed to have preferable drug content. Conclusion: In-vitro dissolution study of atenolol FDS has given an evidence of its high lipophilic and crystalline nature. SD technology and incorporation of superdisintegrants in the tablet formulation containing solid dispersion of drug is a promising methodology to formulate effective FDT of atenolol.

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